Preparation for localized delivery of therapeutic agent

A - Human Necessities – 61 – F

Patent

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A61F 13/00 (2006.01)

Patent

CA 2569072

Disclosed herein is a preparation for topically delivering and localizing therapeutic agents, comprising: a vasoconstrictor for retarding vascular dispersion of a therapeutic agent; and a penetration enhancer for facilitating penetration of the vasoconstrictor and the therapeutic agent through a patient's skin. Further disclosed is an associated method of topically delivering and localizing therapeutic agents, comprising the steps of: using a vasoconstrictor for retarding vascular dispersion of a therapeutic agent; in combination with using a penetration enhancer for facilitating penetration of the vasoconstrictor and the therapeutic agent through a patient's skin. Also disclosed are various courses of treatment, which comprise applying the various disclosed combinations of agents to the patient~s skin.

L'invention concerne une préparation destinée à une administration topique et permettant de localiser de agents thérapeutiques. Cette préparation comprend un vasoconstricteur destiné à retarder la dispersion vasculaire d'un agent thérapeutique et un agent d'amélioration de la pénétration destiné à faciliter la pénétration du vasoconstricteur et de l'agent thérapeutique à travers la peau d'un patient. L'invention concerne également un procédé associé d'administration topique et de localisation d'agents thérapeutiques, ce procédé comprenant les étapes consistant à utiliser un vasoconstricteur pour retarder la dispersion vasculaire d'un agent thérapeutique, en combinaison avec l'utilisation d'un agent d'amélioration de la pénétration destiné à faciliter la pénétration du vasoconstricteur et de l'agent thérapeutique à travers la peau d'un patient. L'invention concerne enfin divers traitements consistant à appliquer les diverses combinaisons d'agents de cette invention sur la peau du patient.

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