Preparation for oxidation-sensitive compounds and method for...

A - Human Necessities – 61 – K

Patent

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A61K 47/02 (2006.01) A61K 8/19 (2006.01) A61K 8/23 (2006.01) A61K 8/27 (2006.01) A61K 8/29 (2006.01) A61K 8/34 (2006.01) A61K 9/107 (2006.01) A61K 31/05 (2006.01) A61Q 19/00 (2006.01)

Patent

CA 2475218

The invention concerns a method which consists in preventing oxidation of an active oxygen-sensitive compound of a medicinal and/or cosmetic formulation including at least a strong antioxidant and at least a weak antioxidant with high coating capacity, the strong antioxidant reacting with the oxygen before the active compound and the weak antioxidant reacting with the residual oxygen to form, after oxidation, highly coating particles which aggregate by micronization around the active compound to form a protective plaster. The invention is applicable in particular to compounds derived from 2,6-di-tert-butylphenol.

Le procédé selon l'invention consiste à éviter l'oxydation d'un composé actif sensible à l'oxygène d'une préparation médicamenteuse et/ou cosmétique en incluant au moins un antioxydant fort et au moins un antioxydant faible à fort pouvoir couvrant, l'antioxydant fort réagissant avec l'oxygène avant le composé actif et l'antioxydant faible réagissant avec l'oxygène résiduel pour former, après oxydation, des particules très couvrantes qui s'agrègent par micronisation autour du composé actif pour former un emplâtre protecteur. Elle s'applique notamment à des composés dérivés du 2,6-di-tert-butylphénol.

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