C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/103.33
C07K 14/755 (2006.01) A61K 35/16 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1269042
ABSTRACT The preparation contains a protein or peptide having a specific Factor VIII:CAg activity greater than 0.5, preferably greater than 1 VIII:CAg unit per mg protein, the ratio between the VIII:CAg activity and the VIII:C procoagulant activity being greater than 5:1, preferably greater than 10:1. A fragment of Factor VIII:C, which displays a doublet of a molecular weight of 77 to 80 kD in electrophoresis, is reactive against hemophilia A inhibitor antibodies and has VIII:CAg activity. This fragment and more low-molecular fragments thereof are capable of neutralizing the coagulation inhibiting effect of all tested antibodies. Such fragments can therefore be used as active component in preparations for providing immunotolerance towards Factor VIII:C in high-dose treatment of inhibitor patients. The peptides are moreover useful as an immunosorbent in specific extraccorporal adsorption treatment of inhibitor patients. The inhibitor reactive peptides can e.g. be recovered from plasma fractions by affinity chromato- graphy, hydrophobic interaction chromatography and cation exchange or they may be produced biosynthetically and recovered in a similar manner.
494555
Nordfang Ole
Rasmussen Mirella Ezban
Nordisk Gentofte A/s
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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