A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/06 (2006.01) A61K 9/70 (2006.01) A61K 31/165 (2006.01) A61K 47/32 (2006.01)
Patent
CA 2056653
Disclosed is a preparation for transdermal drug administration comprising a flexible backing layer and a pressure-sensitive adhesive layer containing a local anesthetic in an amount of 40-65 % by weight based on the total weight of the pressure-sensitive adhesive layer. Since the ratio of the amount of undissolved local anesthetic (Ac) to that of dissolved local anesthetic (As), Ac/As, in the pressure-sensitive adhesive layer is determined to be in the range of 0.1-1.8, the preparation for transdermal drug administration is superior in self-adhesiveness and leaves no adhesive material upon removal from the skin. In addition, burst-like release of the undissolved drug from the pressure-sensitive adhesive layer immediately after application to the skin permits rapid appearance of the anesthetic effect, which enables wide clinical application of the preparations of the present invention.
Hori Mitsuhiko
Kishi Ikuo
Maruyama Koji
Saito Kenichiro
Sunami Masaki
Fetherstonhaugh & Co.
Nitto Denko Corporation
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