A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A61K 9/10 (2006.01) A61K 35/12 (2006.01) A61K 35/34 (2006.01) A61L 27/38 (2006.01) A61L 27/40 (2006.01) A61L 27/54 (2006.01) A61P 9/00 (2006.01)
Patent
CA 2702173
An object of the present invention is to establish a cell transplantation method which can markedly improve the survival of grafted pluripotent stem cells and the efficiency of cardiomyocyte regeneration in cell therapy using pluripotent stem cells derived from heart tissue and can treat heart disease further effectively. Specifically, according to the present invention, enhancement in the survival of grafted pluripotent stem cells and significant improvement in the efficiency of cardiomyocyte regeneration are achieved by using, in combination, pluripotent stem cells derived from heart tissue and a hydrogel containing a basic fibroblast growth factor (bFGF) in cell therapy for heart disease.
La présente invention a pour objectif d'établir une thérapie de transplantation cellulaire en utilisant une cellule souche multipotente dérivée d'un tissu cardiaque, qui peut considérablement améliorer l'adhésion de la cellule souche multipotente et l'efficacité de la régénération d'une cellule de muscle cardiaque, et qui peut traiter une maladie cardiaque plus efficacement. Dans une thérapie de transplantation cellulaire pour une maladie cardiaque, une combinaison d'une cellule souche multipotente dérivée d'un tissu cardiaque et d'un hydrogel contenant un facteur de croissance des fibroblastes basique (bFGF) est utilisée, afin d'améliorer l'adhésion de la cellule souche multipotente et d'améliorer considérablement l'efficacité de la régénération d'une cellule de muscle cardiaque.
Matsubara Hiroaki
Oh Hidemasa
Tabata Yasuhiko
Takehara Naofumi
Kyoto University
Marks & Clerk
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