A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/26 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 31/16 (2006.01) A61K 31/60 (2006.01)
Patent
CA 2274832
The invention relates to a preparation in the form of a compound containing a matrix material, with an auxiliary substance phase with at least one auxiliary substance and/or an active substance phase with at least one active substance, and a matrix material phase with at least one polymer and/or lipid. The invention is characterized in that the matrix material phase of the preparation is incoherent, and the auxiliary and/or active substance phase of the preparation is coherent. In addition, a method for the production of this preparation is described. This preparation is suited for the production of larger matrix units with controlled release characteristics in accordance with known methods, and in particular for the production of tablets by means of direct compressing.
L'invention a pour objet une préparation sous forme d'un composé renfermant un matériau matriciel comprenant une phase matière auxiliaire renfermant au moins une matière auxiliaire, et/ou une phase matière active renfermant au moins une matière active, et une phase matériau matriciel renfermant au moins un polymère et/ou un lipide. L'invention est caractérisée en ce que la phase matériau matriciel de la préparation est incohérente et en ce que la phase matière auxiliaire et/ou matière active de la préparation est cohérente. L'invention concerne en outre un procédé de fabrication de la préparation selon l'invention. Cette préparation convient pour la production de plus grandes unités matricielles à caractéristiques de libération contrôlées, conformément à des procédés connus et, en particulier, à la production de comprimés par pastillage direct.
Blake Cassels & Graydon Llp
Dds Drug Delivery Service Gesellschaft Zur Forderung Der Forschu
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