C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/64 (2006.01) A61K 31/16 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 17/06 (2006.01) A61P 27/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01)
Patent
CA 2748289
The invention provides a new kind of dihydroindene amide compounds of general formula I or their pharmaceutically acceptable salts or prodrug thereof which can be used as protein kinase inhibitor The invention provides a preparation method of the kind of compounds, the pharmaceutical compositions containing the compounds, the method for preventing or curing the diseases related to the abnormity of activities of protein kinases, especially Abl, Bcr-Abl, c-Kit and PDGFR, using them as protein kinase inhibitor, and their preparation use of drug used for preventing or curing the diseases related to the abnormity of activities of protein kinases, especially Abl, Bcr-Abl, c-Kit and PDGFR
L'invention concerne une nouvelle sorte de composés d'amide de dihydroindène de formule générale ? ou leurs sels ou promédicaments pharmaceutiquement acceptables qui peuvent être utilisés comme inhibiteur de protéine kinase. L'invention concerne un procédé de préparation de cette sorte de composés, les compositions pharmaceutiques contenant les composés, la méthode permettant de prévenir ou de soigner les maladies associées à une anomalie dans les activités des protéines kinases, en particulier Abl, Bcr-Abl, c-Kit et PDGFR, leur utilisation comme inhibiteur de protéine kinase et leur utilisation en préparation comme médicament utilisé pour prévenir ou soigner les maladies associées à une anomalie dans les activités des protéines kinases, en particulier Abl, Bcr-Abl, c-Kit et PDGFR.
Luo Juan
Xue Long
Yang Xuqing
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Harbin Gloria Pharmaceuticals Co. Ltd.
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