Preparation of 10-deacetylbaccatin iii and...

C - Chemistry – Metallurgy – 07 – D

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D 305/14 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2187191

The present invention relates to a process for converting purified, partially purified or crude taxane mixtures into a protected precursor of 10-deacetylbaccatin III and into 10-deacetylbaccatin. The process comprises three steps, the first of which includes contacting a mixture containing at least one naturally occurring taxane compound having the structure (II) in which R? is phenyl,(a), or n-C5H?? with at least one hydroxy protecting group. The second step involves cleaving the ester linkage of the protected taxane thus giving rise to a protected precursor of 10-deacetylbaccatin III, the deprotection of which leads to 10-deacetylbaccatin III.

La présente invention se rapporte à un procédé de conversion de mélanges de taxanes purifiés, partiellement purifiés ou bruts en un précurseur protégé de 10-désacétyl-baccatine III et en 10-désacétyl-baccatine III. Ce procédé comprend trois étapes, dont la première consiste à mettre en contact, avec au moins un groupe protecteur hydroxy, un mélange contenant au moins un composé de taxane naturel de structure (II), dans laquelle R¿1? représente phényle, (a) ou n-C¿5?H¿11?. La seconde étape consiste à cliver la liaison ester du taxane protégé pour donner un précurseur protégé de 10-désacétyl-baccatine III, l'enlèvement du groupe protecteur produisant alors 10-désacétyl-baccatine III.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Preparation of 10-deacetylbaccatin iii and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of 10-deacetylbaccatin iii and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of 10-deacetylbaccatin iii and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1492185

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.