C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 305/14 (2006.01) C07F 7/10 (2006.01)
Patent
CA 2187191
The present invention relates to a process for converting purified, partially purified or crude taxane mixtures into a protected precursor of 10-deacetylbaccatin III and into 10-deacetylbaccatin. The process comprises three steps, the first of which includes contacting a mixture containing at least one naturally occurring taxane compound having the structure (II) in which R? is phenyl,(a), or n-C5H?? with at least one hydroxy protecting group. The second step involves cleaving the ester linkage of the protected taxane thus giving rise to a protected precursor of 10-deacetylbaccatin III, the deprotection of which leads to 10-deacetylbaccatin III.
La présente invention se rapporte à un procédé de conversion de mélanges de taxanes purifiés, partiellement purifiés ou bruts en un précurseur protégé de 10-désacétyl-baccatine III et en 10-désacétyl-baccatine III. Ce procédé comprend trois étapes, dont la première consiste à mettre en contact, avec au moins un groupe protecteur hydroxy, un mélange contenant au moins un composé de taxane naturel de structure (II), dans laquelle R¿1? représente phényle, (a) ou n-C¿5?H¿11?. La seconde étape consiste à cliver la liaison ester du taxane protégé pour donner un précurseur protégé de 10-désacétyl-baccatine III, l'enlèvement du groupe protecteur produisant alors 10-désacétyl-baccatine III.
Murray Christopher K.
Zheng Qun Y.
Hauser Inc.
Hauser Chemical Research Inc.
Hauser Chemical Research Inc.
Smart & Biggar
LandOfFree
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