Preparation of 1h-pyrrol-2-acetic acid esters

Details Preparation of 1h-pyrrol-2-acetic acid esters Preparation of 1h-pyrrol-2-acetic acid esters

C - Chemistry, Metallurgy

07

D

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C07D 207/337 (2006.01) C07D 207/34 (2006.01)

Patent

CA 1158249

IMPROVED PREPARATION OF 1H-PYRROL-2-ACETIC ACID ESTERS ABSTRACT OF THE DISCLOSURE A process for the preparation of esters of 1H-pyrrol -2-acetic acids of the formula Image I wherein R1 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and R2 is selected from the group consisting of alkyl of 1 to 4 carbon atoms and aralkyl of 1 to 4 alkyl carbon atoms comprising reacting a compound of the formula Image II wherein R3 is selected from the group consisting of -CN and Image in an aqueous media with a saponification base to obtain the corresponding salt of 1H-pyrrol-2-acetic acid and reacting the latter without isolation with a solution of an alkylating or aralkylating agent in an organic water-insoluble solvent in the presence of a phase transfer agent to obtain the ester of formula I in excellent yields and purity.

392385

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