Preparation of 2-(3-aminopropyl)-cycloalkylamines

Details Preparation of 2-(3-aminopropyl)-cycloalkylamines Preparation of 2-(3-aminopropyl)-cycloalkylamines

C - Chemistry, Metallurgy

07

C

260/605.4

C07C 209/48 (2006.01) C07C 209/26 (2006.01) C07C 211/35 (2006.01)

Patent

CA 2039327

A process for the preparation of a 2-(3-aminopropyl)-cycloalkylamine of the general formula I (see formula I) in which the subscript n is an integer from 1 to 4, from a 2-(2-cyano- ethyl)-cycloalkanone of the general formula II (see formula II) in which the subscript n has the meaning stated, wherein the following stages are carried out in discrete reaction cham- bers: a) the 2-(2-cyanoethyl)-cycloalkanone of formula II is reacted in a first reaction chamber with excess ammonia over an acidic hetero- geneous catalyst at a temperature of from 20° to 150°C and a pressure of from 15 to 500 bar, and b) in a second reaction chamber, the reaction product from stage a) is hydrogenated at a temperature of from 60° to 150°C and a pressure of from 50 to 300 bar in the presence of excess ammonia over a catalyst containing cobalt, nickel, ruthenium, and/or some other noble metal, which catalyst optionally contains a basic component or is supported on neutral or basic supporting material, and the novel compound 2-(3-aminopropyl)-cyclopentylamine.

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