Preparation of 2-aryl-propionic acids by direct coupling...

Details Preparation of 2-aryl-propionic acids by direct coupling... Preparation of 2-aryl-propionic acids by direct coupling...

C - Chemistry, Metallurgy

07

F

260/361, 260/438

C07F 3/02 (2006.01)

Patent

CA 1115722

ABSTRACT OF THE DISCLOSURE Intermediates useful in the preparation of 2-aryl-propionic acids having anti-inflammatory, antipyritic and anelgesic properties are disclosed. Such 2-aryl-propionic acids are prepared by the direct coupling of aryl magnesium bromides, where aryl may be 6-methoxy-2-naphthyl, 4-alkylpnenyl and 4'-fluoro-4-biphenyl with a complex of the formula CH3CH(Br)- COOMgX, wherein X is chloro or bromo. The complex is prepared by treating a Grignard reagent with alpha-bromo-propionic acid.

375597

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