Preparation of 2-aryl-propionic acids by direct coupling...

Details Preparation of 2-aryl-propionic acids by direct coupling... Preparation of 2-aryl-propionic acids by direct coupling...

C - Chemistry, Metallurgy

07

C

260/361, 260/515

C07C 57/32 (2006.01) C07C 53/19 (2006.01) C07C 57/30 (2006.01) C07C 57/58 (2006.01) C07C 59/68 (2006.01) C07C 63/24 (2006.01) C07C 65/24 (2006.01) C07F 3/02 (2006.01)

Patent

CA 1124735

ABSTRACT OF THE DISCLOSURE Intermediates useful in the preparation of 2-aryl-propionic acids having anti-inflammatory, antipyritic and anelgesic properties are disclosed. Such 2-aryl-propionic acids are prepared by the direct coupling of aryl magnesium bromides, where aryl may be 6-methoxy-2-naphthyl, 4-alkylphenyl and 4'-fluoro-4-biphenyl with a complex of the formula CH3CH(Br)- COOMgX, wherein X is chloro or bromo. She complex is prepared by treating a Grignard reagent with alpha-bromo-propionic acid.

296904

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