Preparation of 2-chloro-5-methylpyridine

Details Preparation of 2-chloro-5-methylpyridine Preparation of 2-chloro-5-methylpyridine

C - Chemistry, Metallurgy

07

D

260/297, 260/295

C07D 213/61 (2006.01)

Patent

CA 1233825

ABSTRACT PREPARATION OF 2-CHLORO-5-METHYLPYRIDINE A 2-oxo-5-methyl-5,6-dihalopiperidine is contacted in a high boiling solvent, preferably trichlorobenzene, with a stoichiometric excess, up to 70 mole % excess, of a chlorinating agent, preferably phosphorus oxychloride or phosgene, at an elevated temperature between 80 and 130°C. The solution of 2-chloro-5-methylpyridine so obtained may be used directly for further chlorination to form 2-chloro-5- trichloromethylpyridine with, for example, chlorine gas in the presence of a free radical initiator. This chemical intermediate is useful in the synthesis of certain herbicidal compounds.

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