C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/073 (2006.01) A61K 31/7072 (2006.01) A61P 31/14 (2006.01) C07B 53/00 (2006.01) C07C 67/46 (2006.01) C07C 69/708 (2006.01) C07D 317/18 (2006.01) C07D 411/04 (2006.01) C07H 7/02 (2006.01) C07H 15/00 (2006.01)
Patent
CA 2580457
The present invention provides (i) processes for preparing a 2'-deoxy- 2'~fluoro-2'-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2'-deoxy-2'-fluoro-2'-C-~methyl-.beta.-D-ribofuranosyl nucleosides from a preformed, preferably naturally~-occurring, nucleoside.
L'invention concerne (i) des procédés de préparation de dérivés de 2'-déoxy-2'-fluoro-2'-méthyl-D-ribonolactone, (ii) la conversion de lactones intermédiaires en nucléosides avec une activité anti-HCV puissante, ainsi que les analogues de ceux-ci, et (iii) des procédés de préparation de nucléosides anti-HCV contenant les 2'-déoxy-2'-fluoro-2'-C-méthyl-ß-D-ribofuranosyle nucléosides, à partir d'un nucléoside préformé, de préférence un nucléoside d'origine naturelle.
Chun Byoung-Kwon
Du Jinfa
Rachakonda Suguna
Wang Peiyuan
Pharmasset Inc.
Ridout & Maybee Llp
LandOfFree
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