Preparation of [2-methyl-5-phenyl-3-(piperazin-1-ylmethyl)]...

Details Preparation of [2-methyl-5-phenyl-3-(piperazin-1-ylmethyl)]... Preparation of [2-methyl-5-phenyl-3-(piperazin-1-ylmethyl)]...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/496 (2006.01)

Patent

CA 2604388

A process for the preparation of compounds of Formula (I) and their pharmaceutically acceptable acid addition salt wherein R1 is phenyl or substituted phenyl, R3 is selected from a group of formula (a), n = 0-2 and X = -NCH3, CH2, S, SO, or SO2 wherein R2 and R5 are as defined herein.

La présente concerne un procédé pour la préparation de composés de la formule (I) et de leur sel d'addition acide pharmaceutiquement acceptable, où R1 représente un groupe phényle ou un groupe phényle substitué, R3 est sélectionné dans un groupe de la formule (a), n vaut de 0 à 2 et X représente un groupe -NCH3, un groupe CH2, un atome S, un groupe SO ou un groupe SO2, où R2 et R5 sont tels que définis ici.

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