Preparation of 3-methylquinoline-8-carboxylic acid

Details Preparation of 3-methylquinoline-8-carboxylic acid Preparation of 3-methylquinoline-8-carboxylic acid

C - Chemistry, Metallurgy

07

D

260/289

C07D 215/48 (2006.01)

Patent

CA 2024865

3-Methylquinoline-8-carboxylic acid I (see formula I) and derivatives thereof are prepared by reacting o-toluidine II or a derivative thereof (see formula II) with methacrolein III (see formula III) in 70-90% strength by weight sulfuric acid in the presence of iodine or of an iodine compound, and oxidizing the resulting 3,8-dimethylquinoline IV or a derivative thereof (see formula IV) with nitric acid in a solution containing sulfuric acid, in the presence of vanadium ions, by a process in which, in the sulfuric acid-containing reaction solution of the 3,8-dimethylquinoline IV, the byproducts of the reaction are first decomposed by oxidation, the resulting 3,8-dimethylquinoline solution is concentrated by distillation and the 3,8-dimethylquinoline is then oxidized in situ with nitric acid to give the 3-methylquinoline-carboxylic acid.

Affiliated with

Also associated with

Rating

Preparation of 3-methylquinoline-8-carboxylic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of 3-methylquinoline-8-carboxylic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of 3-methylquinoline-8-carboxylic acid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1659862