C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/520, 260/479
C07C 57/03 (2006.01) C07C 51/12 (2006.01) C07C 57/26 (2006.01) C07C 69/533 (2006.01) C07D 305/12 (2006.01) C07D 309/06 (2006.01)
Patent
CA 1242741
ABSTRACT OF THE DISCLOSURE: The invention relates to a process for the preparation of a 4-substituted but-3-ene-1-carboxylic acid or its esters of the formula (I): Image where R1 is an organic radical, R2 is hydrogen or an organic radical, and R1 and R2 may furthermore be bonded to one another to form a 5-membered to 20-membered ring and should be inert under the reaction conditions des- cribed below, and R3 is hydrogen or lower alkyl, by carbonylation of a derivative of allyl alcohol with the aid of a palladium halide, wherein an allyl alcohol (II): Image (II) is carbonylated with carbon monoxide at 50 - 150°C and under 200 - 700 bar, a) together with an alcohol(III): R3' -OH (III) where R3' is lower alkyl,if a predominant amount of an ester (I) is to be prepared, or b) without any alcohol of formula (III) where an acid(I)is to be prepared; in the presence of an effective amount of a complex of a palladium halide and a tertiary phosphine (IV): Image (IV) where R4, R5 and R6 are each organic radical. This process makes the compounds of formula (I) more readily accessible.
469893
Himmele Walter
Hoffmann Werner
Janitschke Lothar
Basf Aktiengesellschaft
Robic Robic & Associes/associates
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