Preparation of 7-alkenyl-3 quinolinecarbonitriles via a...

C - Chemistry – Metallurgy – 07 – D

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C07D 495/04 (2006.01) C07D 215/54 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2636736

The present invention is directed to a process for preparing compounds of formula (I): wherein A, R1 -R3, X, s, t, u, m and Z are defined herein, comprising the step of reacting a reagent of formula (II): in the presence of Pd(O) metal with a compound of formula (III): or salts thereof. Another aspect of this invention is a method of preparing compounds of formula (VI).

La présente invention concerne un procédé de préparation de composés répondant à la formule (I) : dans laquelle A, R1 à R3, X, s, t, u, m et Z sont définis ici, comprenant l'étape consistant à faire réagir un réactif répondant à la formule (II) : en présence de métal Pd(0) avec un composé répondant à la formule (III) : ou des sels de celui-ci. Un autre mode de réalisation de la présente invention est un procédé de préparation des composés répondant à la formule (VI).

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