Preparation of (7s,...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01)

Patent

CA 2099563

A process for separating the enantiomers (I), (II) of a racemic mixture of trans-2-(2-pyrimidinyl)-7-(hydroxymethyl) octa-hydro-2H-pyrido[1,2-a]pyrazine comprising reacting the racemic mixture with D-(-) or L-( + ) tartaric acid and separating the resulting diastereomeric tartrate salts.

Méthode pour séparer les énantiomères (I), (II) d'un mélange racémique de trans-2-(2-pyrimidinyl)-7-(hydroxyméthyl)octahydro-2H-pyrido¢1,2-a!pyrazine, consistant à faire réagir le mélange avec de l'acide tartrique D-(-) ou L-( + ), et à séparer les sels tartrates diastéréo-isomères résultants.

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