Preparation of a cephalosporin antibiotic using the...

Details Preparation of a cephalosporin antibiotic using the... Preparation of a cephalosporin antibiotic using the...

C - Chemistry, Metallurgy

07

D

C07D 501/46 (2006.01)

Patent

CA 2077780

CT-2179A ABSTRACT The present invention provides an aqueous acylation process for the preparation of antibiotic, cefepime dihydrochloride hydrate which is substantially free of the anti-isomer and the .DELTA.2 isomer comprising the N-acylation of 7-amino- 3-[(1-methyl-l-pyrrolidinio)-methyl]ceph-3-em-4- carboxylate with the syn-isomer of 2-(2-aminothiazol- 4-yl)-2-methoxyimino acetyl chloride hydrochloride.

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