Preparation of a piperidinylclopentylheptenoic acid derivative

Details Preparation of a piperidinylclopentylheptenoic acid derivative Preparation of a piperidinylclopentylheptenoic acid derivative

C - Chemistry, Metallurgy

07

D

260/291, 260/293

C07D 295/155 (2006.01) C07F 5/02 (2006.01)

Patent

CA 1312609

ABSTRACT Preparation of a piperidinylcyclopentylheptenoic acid derivative A process is described for the preparation of a compound of formula (1) (1) Image or a salt thereof, which comprises reacting a compound of formula (2) (2) Image (where A is a displaceable atom or group and R is a hydrogen atom or a C1-6alkyl or C7-20aralkyl protecting group) or a salt thereof, to replace the moiety A with a phenyl group, followed where necessary by removal of a C1-6alkyl or C7-20aralkyl protecting group and/or by salt formation. The replacement of A in formula (2) by a phenyl group may be effected with a compound PhX (3) wherein Ph represents phenyl and X is an atom or group as defined for A in formula (2) or X is a metal atom or metal-containing group or a group SiR'3 (where R' is an alkyl or aryl group) provided that when A is -B(OH)2 X can only represent a conventional leaving group.

570746

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