Preparation of a polymer/interleukin-2 conjugate

Details Preparation of a polymer/interleukin-2 conjugate Preparation of a polymer/interleukin-2 conjugate

C - Chemistry, Metallurgy

07

K

530/17.08, 167/1

C07K 17/08 (2006.01) A61K 38/20 (2006.01) A61K 47/48 (2006.01) C07K 14/55 (2006.01)

Patent

CA 2008142

Abstract The present invention is a process for preparing a pharmaceutical composition comprising a biologically active conjugated protein. It comprises a polyethylene glycol or a polyoxyethylated polyol conjugated to IL-2. This protein is conjugated to reduce its immunogenicity, and increase it solubility, and increase its circulating in vivo half-life.

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