C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
260/460.6
C07F 9/10 (2006.01) C07F 9/09 (2006.01)
Patent
CA 1251462
ABSTRACT OF THE DISCLOSURE The invention relates to a method for preparing 1,2-diacyl-sn-glycero-3-phospho-cholines and 1,2-diacyl-sn- glycero-3-phospho- ethanolamines of the formula Image IV in which R1', R2' and R3' are identical and in each case denote either 3 hydrogen atoms or 3 methyl groups, and R4 and R5 are different and independently of one another denote a straight chain or branched C1 to C24-alkyl radical, a straight chain or branched C1 to C24-alkyl radical substituted by one or more halogen atoms or alkoxy groups, a straight chain or branched monounsaturated or polyunsaturated C3 to C24-alkenyl radical or a straight chain or branched monounsaturated or polyunsaturated C3 to C24-alkenyl radical substituted by one or more halogen atoms or alkoxy groups, which method comprises a) acylating a compound of the formula Image I - 2- in which T denotes a triphenylmethyl group which is unsubstituted or monosubstituted or polysubstituted by C1 to C6-alkyl, C1 to C6-alkoxy or halogen and the radicals R1, R2 and R3 either are identical and each represent a methyl group or are different, in which case two of the radicals R1, R2 and R3 always denote hydrogen and the third radical represents a triphenylmethyl group which is unsubstituted or monosubstituted or polysubstituted by C1 to C6-alkyl, C1 to C6-alkoxy or halogen by reaction with an acylating derivative of the formula R4COOH (b) eliminating the 1-0-Triphenylmethyl- group by the action of acids (c) acylating the free 1-OH-group by reaction with an acylating derivative of the formula R5COOH (d) eliminating any N-triphenylmethyl-group which is still present, by the action of an acid.
552926
Hermetter Albin
Paltauf Friedrich
Chemie Linz Aktiengesellschaft
Riches Mckenzie & Herbert Llp
LandOfFree
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