Preparation of alkoxypyridyl derivatives which are histamine...

Details Preparation of alkoxypyridyl derivatives which are histamine... Preparation of alkoxypyridyl derivatives which are histamine...

C - Chemistry, Metallurgy

07

D

260/291.5

C07D 213/32 (2006.01) C07D 213/65 (2006.01) C07D 213/68 (2006.01) C07D 213/79 (2006.01)

Patent

CA 1068711

ABSTRACT OF THE DISCLOSURE Pharmacologically active compounds are disclosed having the formula: Image FORMULA I Where Het is a grouping of the formula: Image wherein R' is lower alkyl or -(CH2)pA where p is 2 to 4 and A is hydroxy, lower alkoxy or dimethylamino; R2 is hydrogen, lower alkyl, lower alkoxy, amino, halogen, or methylamino; or -OR' and R2 can together form a -O(CH2)qO- group attached to adjacent carbon atoms on the pyridine ring, where q is 1 to 4; Z is sulphur or methylene; n is 2 or 3; X is sulphur, CHNO2, NH, NCN or NOH; Y is hydrogen, lower alkyl, 2-hydroxyethyl or Het'CH2Z'(CH2)n,-, where Het' has the same scope as Het in Formula 1 or is an imidazolyl ring optionally substituted by methyl or bromo, a pyridyl ring optionally substituted by hydroxy, chlorine or bromine, a thiazolyl ring or an isothiazolyl ring; Z' is sulphur, or methylene; and n' is 2 or 3. These compounds are useful for blocking or inhibiting the actions of histamine H2-receptors.

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