Preparation of alkylphosphocholines

Details Preparation of alkylphosphocholines Preparation of alkylphosphocholines

C - Chemistry, Metallurgy

07

F

C07F 9/10 (2006.01) C07F 9/09 (2006.01)

Patent

CA 2073126

A process for the preparation of C14 - C18 alkyl- phosphocholines comprises reacting an n-alkanol having a chain length of C14 to C18 with phosphorus oxychloride in a single reaction vessel. The product obtained is reacted with a choline salt in the presence of a basic substance, without isolation and purification, in an inert solvent, to form a corresponding phosphoric acid diester chloride. The phosphoric acid diester chloride is hydrolyzed to obtain the alkylphosphocholine. Purification of C14 - C18 alkylphosphocholines is performed by adding to a solution of an alkylphosphocholine, in a solvent selected from the group consisting of anhydrous alcohols with 1 to 5 carbon atoms, water and any mixture of said alcohols with or without water, a mixed-bed ion-exchanger, or successively or simultaneously at least one ion-exchanger selected from the group consisting of an acid ion-exchanger and a basic ion-exchanger. The solution and the ion-exchanger are stirred together, and the solution is separated from the ion-exchanger to recover purified alkylphosphocholine.

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