Preparation of .alpha.-amino carboxylic acid amides

Details Preparation of .alpha.-amino carboxylic acid amides Preparation of .alpha.-amino carboxylic acid amides

C - Chemistry, Metallurgy

07

C

C07C 231/06 (2006.01) C07C 237/06 (2006.01) C07C 237/24 (2006.01)

Patent

CA 2274527

Method of preparing .alpha.-amino carboxylic acid amides directly from aminonitriles in high yield and purity by acid hydrolysis. The method involves preparing the amide salt such as amide hydrochloride directly from the corresponding aminonitrile in the presence of water, a strong mineral acid such as anhydrous HCl, and an organic solvent in which the resulting amide salt is insoluble or substantially insoluble. Suitable organic solvents include dialkyl ethers, dialkyl ethylene glycol ethers and secondary alcohols.

Procédé permettant de préparer des amides de l'acide .alpha.-amino-carboxylique directement à partir d'aminonitriles, avec des rendements et une pureté élevés, par hydrolyse acide. Selon le procédé, on prépare le sel d'amide, le chlorhydrate d'amide par exemple, directement à partir de l'aminonitrile correspondant en présence d'eau, d'un acide minéral fort tel que le HCl anhydre, et d'un solvant organique dans lequel le sel d'amide obtenu est insoluble ou sensiblement insoluble. Les solvants organiques appropriés sont les dialkyléthers, les dialkyl-éthylèneglycol-éthers et les alcools secondaires.

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