Preparation of aminocyclopentane acids

Details Preparation of aminocyclopentane acids Preparation of aminocyclopentane acids

C - Chemistry, Metallurgy

07

D

260/293.1, 260/2

C07D 295/14 (2006.01) C07D 295/096 (2006.01) C07D 295/112 (2006.01) C07D 295/116 (2006.01) C07D 295/155 (2006.01) C07D 311/00 (2006.01) C07D 409/12 (2006.01)

Patent

CA 1191136

ABSTRACT A process is described for the preparation of compounds of the formula Image in which W is C1-7 alkylene X is cis or trans -CH=CH- or -CH2CH2- Y is a saturated heterocyclic amino group, and R2 is substituted or unsubstituted phenyl-, thienyl- or naphthyl-alkyl, or cinnamyl, and their salts and solvates. The process comprises hydrolysing a corresponding ester, amide, nitrile or ortho-ester. The starting materials are preferably prepared by reducing the corresponding cyclopentanone and hydrolysis can take place simultaneously with reduction.

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