Preparation of an atorvastatin intermediate

Details Preparation of an atorvastatin intermediate Preparation of an atorvastatin intermediate

C - Chemistry, Metallurgy

07

C

C07C 231/12 (2006.01) C07C 235/80 (2006.01)

Patent

CA 2621507

The diketone of atorvastatin is prepared by first washing a reaction vessel with a non-ketonic solvent, especially tetrahydrofuran, to remove water. 4- fluorobenzaldehyde is then reacted with benzylidine isobutyryl acetanilide in the reaction vessel to form 4-fluoro-alpha-(2-methyl-l-oxopropyl)-gamma-oxo- N,beta- diphenylbenzene-butanamide

L~invention concerne un procédé de préparation de dicétone d~atorvastatine, consistant tout d~abord à rincer une cuve de réaction avec un solvant non cétonique, notamment le tétrahydrofuranne, afin d~éliminer l~eau. Du 4-fluorobenzaldéhyde est ensuite mis en réaction avec du benzylidine isobutyryle acétanilide dans la cuve de réaction afin de former du 4-fluoro-alpha-(2-méthyl-1-oxopropyl)-gamma-oxo-N,bêta-diphénylbenzène-butanamide.

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