C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
260/361.3, 260/3
C07F 9/655 (2006.01) C07D 407/04 (2006.01)
Patent
CA 2012926
- 28 - O.Z. 0050/40665 Abstract of the Disclosure: Ascorbic acid 2-phosphate is prepared by reacting ascorbic acid or an ascorbic acid derivative with POCl3 in the presence of a tertiary amine in a suitable aqueous solvent at from -10 to 25°C while maintaining a pH of about 8-13.5 with KOH during the entire phosphorylation reaction and then isolating -the ascorbic acid 2-phosphate, by a process in which an aqueous solution of a magnesium compound is added to the reaction mixture obtained in the phosphorylation, without prior treatment with an ion exchanger, until the forma- tion of crystalline KMgPO4 is complete, the KMgPO4 which is crystallized out is separated off, the resulting fil- trate is evaporated down at a pH of from 6 to 11 and/or from 0.1 to 5 times the amount, based on the evaporated filtrate, of a lower primary alkanol or acetone is added and the stirred mixture is cooled until KCl has completely crystallized out, and the ascorbic acid phosphate is iso- lated in a conventional manner from the reaction solution obtained by separating off KCl and substantially freed from inorganic salts. It is particularly advantageous if the ascorbic acid 2-phosphate is isolated in the form of the novel potassium magnesium ascorbate 2-phosphate, which is also claimed. The process is particularly advantageous if the ascorbic acid derivative used is 5,6-isopropylidene- ascorbic acid which has been obtained by reacting ascor- bic acid with acetone in the presence of oleum. The process is particularly important for the preparation of L-ascorbic acid 2-phosphate.
Betz Roland
Dobler Walter
Paust Joachim
Basf Aktiengesellschaft
Robic Robic & Associes/associates
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