C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/645.7, 260/6
C07C 1/26 (2006.01) C07C 1/32 (2006.01) C07C 15/14 (2006.01) C07C 41/30 (2006.01) C07C 43/205 (2006.01)
Patent
CA 2000579
ABSTRACT OF THE DISCLOSURE A method for the preparation of biaryl compounds is disclosed which comprises contacting an aryl halide under conditions suitable to form a Grignard reagent and thereafter contacting the Grignard reagent with an aryl chloride in the presence of a catalyst comprising a nickel compound and a coordinating ligand under conditions suitable for the formation of biaryl compound. In an alternate embodiment of the present invention, biaryl compounds are prepared directly from aryl halides in a single reaction vessel by contacting aryl halide with elemental magnesium and a nickel catalyst comprising a nickel compound and a coordinating ligand in an aprotic, non-polar, ether-containing solvent system for a time and under conditions suitable for the formation of biaryl compound. LE0757F
Eastman Chemical Company
Gowling Lafleur Henderson Llp
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