C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/50 (2006.01) C07C 62/24 (2006.01) C07C 227/24 (2006.01) C07D 235/02 (2006.01)
Patent
CA 2224235
A process for the preparation of (+)-2-amino-bicyclo[3.1.0]-hexane-2-6- dicarboxylic acid, or a pharmaceutically acceptable salt thereof, which comprises hydrolysing (-)-2-spiro-5'-hydantoinbicyclo[3.1.0]hexane-6- carboxylic acid or a salt thereof, and optionally forming a pharmaceutically acceptable salt. Also disclosed are novel intermediates useful in the process.
On décrit un procédé de préparation de l'acide (+)-2-amino-bicyclo[3.1.0]-hexane-2-6-dicarboxylique, ou d'un sel de celui-ci acceptable sur le plan pharmacologique, ce procédé consistant à hydrolyser de l'acide (-)-2-spiro-5'-hydantoïnbicyclo[3.1.0]hexane-6-carboxylique, ou un sel de celui-ci, puis à former, le cas échéant, un sel acceptable sur le plan pharmacologique. On décrit également de nouveaux intermédiaires utiles dans ce procédé.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
LandOfFree
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