Preparation of candesartan cilexetil

C - Chemistry – Metallurgy – 07 – D

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C07D 403/10 (2006.01)

Patent

CA 2542499

The invention encompasses processes for the synthesis of cilexetil trityl candesartan from the reaction of trityl candesartan with cilexetil halide in the presence of a base and a low boiling organic solvent. Optionally, the reaction may be conducted in the presence of a phase transfer catalyst.

L'invention concerne des procédés de synthèse de candésartan trityle cilexetil à partir de la réaction de candésartan trityle avec de l'halogénure de cilexetil en présence d'une base et d'un solvant organique à point d'ébullition bas. Eventuellement, la réaction peut être conduite en présence d'un catalyseur de transfert de phase.

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