Preparation of clavulanate salts

C - Chemistry – Metallurgy – 07 – D

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C07D 503/02 (2006.01) C07D 503/00 (2006.01) C07D 503/18 (2006.01) C12P 17/18 (2006.01)

Patent

CA 2218648

A process for preparation and/or purification of clavulanic acid or a pharmaceutically acceptable salt or ester thereof, including the steps of: adding an additional solvent to a solution of clavulanic acid in a water immiscible solvent; contacting the solution with an amine; isolating the amine salt of clavulanic acid formed; and converting the amine salt into clavulanic acid or a pharmaceutically acceptable salt or ester thereof.

L'invention concerne un procédé de préparation et/ou de purification de l'acide clavulanique, d'un ester ou d'un sel de celui-ci acceptable sur le plan pharmaceutique, consistant à : ajouter un solvant additionnel à une solution d'acide clavulanique dans un solvant non miscible avec l'eau; mettre la solution en contact avec une amine; isoler le sel amine de l'acide clavulanique formé; et convertir le sel d'amine en acide clavulanique ou en un ester ou un sel de celui-ci acceptable sur le plan pharmaceutique.

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