Preparation of clevidipine butyrate ring the same

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 211/90 (2006.01)

Patent

CA 2701087

Clevidipine butyrate, O3-(butanoyloxymethyl)-O5-methyl-4-(2,3-dichlorophenyl)- 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, is prepared by the alkylation of 4-(2,3-dichiorophenyl)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-3- pyridinecarboxylic acid tetramethylammonium hydroxide, with chloromethyl butyrate.

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