Preparation of compounds of lignan series

Details Preparation of compounds of lignan series Preparation of compounds of lignan series

C - Chemistry, Metallurgy

07

C

C07C 69/94 (2006.01) C07C 67/347 (2006.01) C07D 317/70 (2006.01) C07D 319/22 (2006.01) C07D 321/10 (2006.01)

Patent

CA 2138264

This invention relates to a process for preparation of compounds of the lignan series in a regioselective manner. This invention provides a process for preparing a compound of the formula (I): which process is characterized in that a lactone compound represented by the formula (II) is allowed to react with a compound of the formula: R7Cl in the presence of a base, then the resulting compound is subjected to an addition reaction with an acetylenic compound of the formula (III), then the resulting compound is reduced; in which R1 is alkyl, cycloalkyl, cycloalkyl lower alkyl, or aralkyl and the like; R2 and R3 are each lower alkoxy and the like; R4 is lower alkoxy or hydrogen; and R5 and R6 are each lower alkyl; and R7 is tri(lower alkyl)silyl. Image

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