Preparation of controlled release skeletal muscle relaxant...

Details Preparation of controlled release skeletal muscle relaxant... Preparation of controlled release skeletal muscle relaxant...

A - Human Necessities

61

K

A61K 9/52 (2006.01) A61K 9/14 (2006.01) A61K 31/137 (2006.01) A61K 47/38 (2006.01) A61P 21/02 (2006.01)

Patent

CA 2727935

The present invention is directed to a method of preparing an extended release pharmaceutical composition com-prising cyclobenzaprine, comprising coating inert particles with a cyclobenzaprine- containing a drug layering composition to form I R beads, then coating the I R beads with an extended-release coating to form E R beads.

La présente invention concerne un procédé pour élaborer une composition pharmaceutique à libération prolongée à base de cyclobenzaprine, ce procédé consistant à enduire des particules inertes avec composition formant une couche de médicament contenant de la cyclobenzaprine de façon à obtenir des granules à libération immédiate, puis à enduire ces granules à libération immédiate d'une couche pour libération prolongée de façon à obtenir des granules à libération prolongée.

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