Preparation of dehydropeptides

Details Preparation of dehydropeptides Preparation of dehydropeptides

C - Chemistry, Metallurgy

07

K

530/5.04, 530/7.

C07K 1/02 (2006.01) C07K 5/062 (2006.01) C07K 5/078 (2006.01) C07K 5/083 (2006.01) C07K 5/097 (2006.01) C07K 5/103 (2006.01) C07K 5/117 (2006.01)

Patent

CA 1141374

ABSTRACT OF THE DISCLOSURE A preparation of azlactones represented by the formula Image II wherein R is a substituted or unsubstituted alkyl, aryl or nitrogen containing hetero- cyclic group, and R1 is an N-blocked amino acid residue or peptide chain, and stereo- isomers thereof, by oxidizing tne corresponding saturated azlactone with a benzo- quinone oxidizing agent in the presence of a base is disclosed. The unsaturated azlactones, some of which are novel, can be converted to dehydro peptides, which are useful as intermediates for preparing novel biologically active compounds, or themselves have biological activity.

330262

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