Preparation of diagnostic agents

Details Preparation of diagnostic agents Preparation of diagnostic agents

B - Operations, Transporting

01

J

B01J 13/04 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 49/00 (2006.01) A61K 49/22 (2006.01)

Patent

CA 2083260

2083260 9218164 PCTABS00016 Microcapsules are prepared by a process comprising the steps of (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microcapsules and (ii) reducing the water-solubility of at least the outside of the intermediate microcapsules. Suitable wall-forming materials include proteins such as albumin and gelatin. The microcapsules have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of median size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced.

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