A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2427625
A method for preparing poorly water soluble drug particles is disclosed. The method comprises dissolving a drug in at least one organic solvent to form a drug/organic mixture, spraying the drug/organic mixture into an aqueous solution and concurrently evaporating the organic solvent in the presence of the aqueous solution to form an aqueous dispersion of the drug particles. The resulting drug particles are in the nanometer to micrometer size range and show enhanced dissolution rates and reduced crystallinity when compared to the unprocessed drug.
L'invention concerne un procédé de fabrication de particules de médicament faiblement solubles dans l'eau. Ce procédé consiste à dissoudre un médicament dans au moins un solvant organique afin de former un mélange médicament/organique, pulvériser ledit mélange médicament/organique dans une solution aqueuse et faire évaporer en même temps le solvant organique en présence de la solution aqueuse en vue de composer une dispersion aqueuse de particules de médicament. Les particules de médicament ainsi obtenues sont comprises dans la gamme de taille du nanomètre au micromètre et présentent de meilleures vitesses de dissolution et une cristallinité réduite lorsque l'on compare celle-ci à un médicament non traité.
Chen Xiaoxia
Johnston Keith P.
Williams Robert O.
Young Timothy J.
Board Of Regents University Of Texas System
Smart & Biggar
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