C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 223/22 (2006.01)
Patent
CA 2648916
A process for preparing a compound of the formula IA or IB, wherein R is a!kyl, aminoalkyl, halogenalkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkoxy, phenyl or substituted phenyl or pyridyl group; the term alkyl means carbon chain, straight or branched, containing from 1 to 18 carbon atoms; the term halogen represents fluorine, chlorine, bromine or iodine; the term cycloalkyl represents a saturated alicyclic g.tau.oup with 3 to 6 carbon atoms; the term aryl represents unsubstituted phenyl group or phenyl substituted by alkoxy, halogen or nitro group, the process comprising asymmetric hydrogenation of a compound of the formula II, wherein R has the same meanings as above, using a chiral catalyst and a source of hydrogen.
L'invention concerne un procédé de préparation d'un composé de formule (IA) ou (IB), dans lesquelles R représente un groupe alkyle, aminoalkyle, halogénoalkyle, aralkyle, cycloalkyle, cycloalkylalkyle, alcoxy, phényle, phényle substitué ou pyridyle, le terme alkyle désignant une chaîne carbonée, linéaire ou ramifiée, contenant de 1 à 18 atomes de carbone, le terme halogène désignant le fluor, le chlore, le brome ou l'iode, le terme cycloalkyle désignant un groupe alicyclique saturé comptant de 3 à 6 atomes de carbone, le terme aryle désignant un groupe phényle non substitué ou un groupe phényle à substitution alcoxy, halogène ou nitro. Ledit procédé comprend l'hydrogénation asymétrique d'un composé de formule (II), dans laquelle R est tel que défini précédemment, au moyen d'un catalyseur chiral et d'une source d'hydrogène.
Learmonth David
Li Wenge
Yu Bing
Bial - Portela & C.a. S.a.
Sim & Mcburney
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