Preparation of esters and analogs thereof

Details Preparation of esters and analogs thereof Preparation of esters and analogs thereof

C - Chemistry, Metallurgy

07

C

C07C 317/24 (2006.01) A61K 31/18 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61P 19/00 (2006.01) C07C 311/16 (2006.01) C07D 207/30 (2006.01) C07D 213/55 (2006.01) C07D 307/34 (2006.01) C07D 333/18 (2006.01) C07D 333/26 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01) C07D 471/04 (

Patent

CA 2293952

Intermediates are disclosed for the preparation of a class of 3, 4-diaryl substituted furan compounds which have utility, amongst others, of being active ingredients for pharmaceutical compositions to treat inflammation and inflammation-related disorders. The intermediates are compounds of the Formula 15 (see formula I) wherein, in the above formulae, R2 and R3 are independently selected from C6-C12-aryl and heteroaryl, optionally substituted at a substitutable position with a radical selected from halo, C1-C10-alkyl, C1-C10-alkoxy, C1-C10-alkylthio, C1-C10-alkylsulfinyl, C1-C10-alkylsulfonyl, nitro, amide, amino, C1-C10-alkyl amino, sulfamyl and C1-C10-alkylsulfonylamino; provided that at least one of R2 or R3 is substituted with C1-C10-alkylsulfonyl or sulfamyl; or an analog. There are also disclosed processes for preparing intermediates of Formula 15 by reacting a compound of the Formula 14 (see formula II) with a compound of the Formula 14(a) Image as defined above.

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