Preparation of factor ix

Details Preparation of factor ix Preparation of factor ix

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 9/08 (2006.01) A61K 38/48 (2006.01) A61K 47/02 (2006.01) C07K 16/40 (2006.01) C12N 9/96 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2105282

A novel method of protecting blood coagulation factor IX from proteases during purification or storage is disclosed. High concentrations of one or more water soluble organic or inorganic salts are used to stabilize factor IX, contained within blood plasma-derived solutions, or contained within solutions derived from other sources, against conversion to clinically unacceptable peptide structures such as factor IX a, and/or degraded Factor IX peptides. The technique is useful in stabilizing intermediate purity factor IX preparations during purification, and in maintaining the integrity of purified factor IX during long term storage. Stable high specific activity factor IX preparations are also disclosed.

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