Preparation of further diagnostic agents

Details Preparation of further diagnostic agents Preparation of further diagnostic agents

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 49/22 (2006.01) B01J 13/04 (2006.01)

Patent

CA 2146783

Microspheres are prepared by a process comprising the steps of (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microspheres and (ii) reducing the water-solubility of at least the outside of the intermediate microspheres. Suitable wall-forming materials include proteins such as albumin and gelatin. The microsphere have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of median size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced. In particular, the microspheres may be 15-20 µm, targeted to selected areas of the body or of prolonged life in the circulation.

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