C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0783 (2010.01) C12N 5/078 (2010.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2665568
Methods of processing inactivated artificial antigen presenting cells (aAPCs) and artificial antigen presenting cells with specificity for selected antigenic peptides are described, including their generation and use in cell therapy compositions comprising activated cytotoxic T lymphocytes. Inactivated aAPCs are advantageously generated through crosslinking, such as via a photoreaction involving a psoralen derivative and UVA irradiation.
La présente invention concerne des procédés de traitement de cellules présentant l'antigène artificielles (artificial Antigen Presenting Cells: aAPC) inactivées et de cellules présentant l'antigène artificielles avec une spécificité envers des peptides antigéniques choisis, ainsi que leur génération et leur utilisation dans des compositions de thérapie cellulaire comprenant des lymphocytes T cytotoxiques activés. Les aAPC inactivées sont générées de manière avantageuse par réticulation, par exemple par une photo-réaction mettant en jeu un dérivé de psoralène et un rayonnement UVA.
Cai Zeling
Degraw Juli
Leturcq Didier
Moriarty Ann
Shi Wei-Xing
Janssen Pharmaceutica N.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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