Preparation of iodixanol

Details Preparation of iodixanol Preparation of iodixanol

C - Chemistry, Metallurgy

07

C

C07C 231/24 (2006.01) C07C 231/08 (2006.01) C07C 237/46 (2006.01)

Patent

CA 2356942

A process for the preparation of iodixanol by dimerisation of 5-ac-etamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide ("Compound A") in which, after the dimerisation step, unreacted Compound A is precipitated from the reaction mixture and recovered for re-use. The process substantially increases the net yield of iodixanol and simplifies its purification.

L'invention concerne un procédé relatif à l'élaboration d'iodixanol par dimérisation de 5-acétamido-N-N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide ("composé A"). Après l'étape de dimérisation, la partie du composé A n'ayant pas réagi est précipitée depuis le mélange réactif et récupérée en vue d'une réutilisation. Ledit procédé augmente sensiblement le rendement net d'iodixanol et simplifie la purification de ce produit.

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