Preparation of iodixanol

Details Preparation of iodixanol Preparation of iodixanol

C - Chemistry, Metallurgy

07

C

C07C 231/24 (2006.01) C07C 237/46 (2006.01)

Patent

CA 2575088

A process for the manufacture of iodixanol by performing a purification process of the crude product in a solvent comprising 1-metoxy-2-propanol. The crude product may be obtained in aqueous solution from dimerisation of 5- acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide ("Compound A").

L'invention concerne un procédé relatif à l'élaboration d'iodixanol par un procédé de purification de produit brut dans un solvant comprenant 1-méthoxy-2-propanol. Le produit brut peut être obtenu dans une solution aqueuse par dimérisation de 5-acétamino-N-N' bis (2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide ("composé A").

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