Preparation of irrigating solution for ocular surgery

A - Human Necessities – 61 – K

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A61K 9/08 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2347921

A one-pack perfusate preparation for ophthalmic operation of cataract, glaucoma or intraocular lens transplantation, which is excellent in the protection of ophthalmic tissues and endothelial cells during and after the operation and has a high in vivo stability. The preparation comprises an aqueous solution of at least one compound selected among D-3-hydroxybutyric acid and water-soluble salts thereof, at least one compound selected among water-soluble bicarbonates, phosphoric acid and water-soluble phosphates, a water-soluble calcium salt, and a water-soluble magnesium salt.

Cette préparation de perfusat, à conditionnement unique, utilisable pour une opération de la cataracte, une intervention relative à un glaucome ou une implantation de lentille intra-oculaire, protège remarquablement les tissus ophtalmiques et les cellules endothéliales durant l'intervention ainsi qu'à la suite de celle-ci et est dotée d'une excellente stabilité in vivo. Cette préparation est à base d'une solution aqueuse d'au moins un composé sélectionné entre un acide hydroxybutyrique-3-D et les sels hydrosolubles de celui-ci ainsi que d'au moins un composé sélectionné dans le groupe constitué par de l'acide phosphorique, des bicarbonates, des phosphates, un sel de calcium et un sel de magnésium hydrosolubles.

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