Preparation of isoflurane

Details Preparation of isoflurane Preparation of isoflurane

C - Chemistry, Metallurgy

07

C

C07C 43/12 (2006.01) C07C 41/22 (2006.01) C07C 41/24 (2006.01)

Patent

CA 2090935

An improved process for the production of isoflurane is disclosed. Isoflurane is formed by the exhaustive chlorination of 2,2,2-trifluoro- ethyl difluoromethyl ether with chlorine gas. The reaction mixture, preferably without purification or refining, is treated with UV light in the presence of isopropanol to reduce 1,1-dichloro-2,2,2-trifluoroethyl difluoromethyl ether, the other major component thereof, to isoflurane. Isoflurane is thereby obtained in yields of at least 80%.

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