Preparation of isolated agonist anti-edar monoclonal antibodies

Details Preparation of isolated agonist anti-edar monoclonal antibodies Preparation of isolated agonist anti-edar monoclonal antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2757114

The present invention concerns the preparation of substantially purified agonist anti- EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof. The invention further relates to isolated agonist anti- EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof as well as their use in the treatment of X-lmked hypohidrotic ectodermal dysplasia and tooth agenesis. The invention also relates to a pharmaceutical composition comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof and to a method of treating X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. Finally, the present invention concerns a pharmaceutical kit comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof.

La présente invention concerne la préparation d'anticorps monoclonaux anti-EDAR agonistes sensiblement purifiés ou de fragments desdits anticorps monoclonaux ou de parties liant l'antigène desdits anticorps monoclonaux ou de fragments de celles-ci, tous isolés. L'invention concerne en outre des anticorps monoclonaux anti-EDAR agonistes isolés, ou des fragments desdits anticorps monoclonaux ou des parties liant l'antigène desdits anticorps monoclonaux ou des fragments de celles-ci, tous isolés, ainsi que leur utilisation dans le traitement de la dysplasie ectodermique hypohidrotique liée à l'X et de l'agénésie dentaire. L'invention concerne également une composition pharmaceutique comprenant lesdits anticorps monoclonaux anti-EDAR agonistes isolés, ou fragments desdits anticorps monoclonaux ou parties liant l'antigène desdits anticorps monoclonaux ou fragments de celles-ci, tous isolés, ainsi qu'une méthode de traitement de la dysplasie ectodermique hypohidrotique liée à l'X et de l'agénésie dentaire. Enfin, la présente invention concerne une trousse pharmaceutique comprenant lesdits anticorps monoclonaux anti-EDAR agonistes isolés, ou fragments desdits anticorps monoclonaux ou parties liant l'antigène desdits anticorps monoclonaux ou fragments de celles-ci, tous isolés.

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