Preparation of isotopically labelled aminopyrine

C - Chemistry – Metallurgy – 07 – D

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260/315.4

C07D 231/22 (2006.01)

Patent

CA 1097357

16139 TITLE OF THE INVENTION Preparation of Isotopically Labelled Aminopyrine ABSTRACT OF THE DISCLOSURE The present invention relates to preparation of isotopically labelled amines by alkylation with isotopic- ally labelled methyl iodide in the presence of an organic material capable of reaction with the formed hydrogen iodide. Such methylated amines, particularly isotopically labelled aminopyrine, are useful as clinical diagnostic aids in liver function tests.

293632

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